Erythrocytosis2025-05-20T13:54:18+01:00

Erythrocytosis

Erythrocytosis is a condition in which your body produces too many red blood cells (RBCs). This increases the thickness (viscosity) of your blood, making it harder to flow smoothly through your blood vessels and increasing the risk of blood clots, heart attacks, or strokes.

It is sometimes referred to as polycythaemia, especially when caused by bone marrow disorders.

Erythrocytosis Overview

Understanding Causes, Symptoms, and Risk Factors

Causes

Erythrocytosis can be primary (due to a problem in the bone marrow) or secondary (due to another condition or factor).

Primary Erythrocytosis
Polycythaemia vera (PV) is a A rare blood cancer caused by a mutation in the JAK2 gene, leading to uncontrolled RBC production.Secondary Erythrocytosis

  • Chronic low oxygen (hypoxia) due to lung disease (e.g. COPD), sleep apnoea or living at high altitudes

  • Tumours producing erythropoietin (EPO) from kidney, liver, or adrenal gland tumours

  • Kidney disease

  • Anabolic steroid use

  • Congenital heart disease

  • Smoking

  • Dehydration (relative erythrocytosis)

Symptoms

  • Headaches
  • Dizziness or lightheadedness
  • Blurred vision
  • Red or flushed skin (especially face)
  • Itching (particularly after a hot shower – in PV)
  • Fatigue
  • High blood pressure
  • Numbness or tingling in hands and feet
  • Enlarged spleen (splenomegaly)

If left, untreated may increase the risk of blood clots, stroke or a heart attack.

Risk Factors

Genetic erythrocytosis can run in families associated with the JAK2 gene mutation.

More common in men than women.

Conditions such as chronic lung disease and kidney disorders.

Can Erythrocytosis be prevented?

Primary erythrocytosis cannot be prevented however secondary erythrocytosis can be prevented.

Secondary Erythrocytosis can prevented by managing the underlying condition and maintaining  adequate hydration.

How Chequers can help Diagnose and Treat

Venesection

Patient having an iron infusion by a clinician

An effective treatment for Erythrocytosis.


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