Haemochromatosis2025-05-20T12:29:01+01:00

Haemochromatosis

A condition where the body absorbs too much iron from the diet. This excess iron builds up in organs — especially the liver, heart, and pancreas — and can cause serious damage over time.AAAA A condition where the body absorbs too much iron from the diet. This excess iron builds up in organs such as the liver, heart, and pancreas and can cause damage over time.

Haemochromatosis Overview

Understanding Causes, Symptoms, and Risk Factors

Causes

Genetic Haemochromatosis (Hereditary)
Caused by

  • mutations in the HFE gene (most commonly C282Y and H63D mutations).
  • Inherited in an autosomal recessive pattern — both parents must pass on the faulty gene.
  • Most common in people of Northern European descent.

Secondary (Acquired) Haemochromatosis

Caused by other conditions such as

  • Repeated blood transfusions
  • Chronic liver disease
  • Certain types of anaemia (e.g. thalassaemia, sideroblastic anaemia)
  • Excessive iron supplements (rare)

Symptoms

  • Fatigue, weakness or joint pain
  • Bronze, greyish skin tone
  • Enlarged liver, cirrhosis, liver damage
  • Diabetes
  • Irregular heartbeat, heart failure
  • Loss of libido, erectile dysfunction, menstrual irregularities
  • Arthritis like symptoms

Risk Factors

Having two copies of the mutated HFE gene (C282Y)

In men between the ages of 30-40 and women after menopause.

More common in men. Women tend to lose iron through menstruation and pregnancy.

Conditions like hepatitis C or fatty liver disease.

Can Haemochromatosis be prevented?

Hereditary haemochromatosis cannot be prevented due to it being a genetic condition but complications can be prevented or minimised.

Early Detection and managing symptoms before they start is key.
Genetic Screening – If you have a family history of haemochromatosis then you can be tested for the HFE gene mutation.
Routine Blood tests – Testing for ferritin and transferrin saturation can detect iron overload before symptoms start.

How Chequers can help Diagnose and Treat

Venesection

Patient having an iron infusion by a clinician

An effective treatment for haemochromatosis


Preventive, Trusted, and Affordable Healthcare for All

Chequers Health is a well-known private healthcare provider in Bolton. It is registered with the CQC and trusted by many patients in the Northwest of England. Our dedicated team is committed to providing personalised care tailored to each patient’s unique needs and exceptional care.

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Had an amazing experience here today. Staff were super friendly, facilities are very good and very clean!

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Our Clinicians

At Chequers Health, our specialists blend expertise, compassion, and convenience to deliver the care you deserve. We prioritise quick access and personalised care, ensuring that your health needs are addressed promptly and effectively by trusted professionals.

Dr Ushma Meswani, BSc. (MBBS), MD, MRCP, FRCPath
Dr Ushma Meswani, BSc. (MBBS), MD, MRCP, FRCPath
Dr. Maged Gharib MBChi, MSc, MD, FRCP, FRCPath
Dr. Maged Gharib MBChi, MSc, MD, FRCP, FRCPath

Frequently Asked Questions

You will need to come into clinic for a short period of time before the infusion, for the duration of the infusion and you will then be asked to stay for further monitoring for about 30 minutes after the infusion.

Oral iron is used initially to treat iron deficiency anaemia. Sometimes this does not produce enough of an improvement, or it may be that your doctor needs to replenish your iron quickly. Intravenous iron is used when oral iron has been tried or if it is not suitable and it helps to reduce the use of blood transfusions.

Intravenous iron is an extremely safe and effective therapy. Some of the side effects that have been reported are:

  1. Staining – If your cannula was to displace from your vein during treatment the drug could be deposited in your skin rather than into your bloodstream. This could result in a brown stain to the skin. If you notice pain at the injection site during your treatment, please inform the nurse caring for you immediately. This will minimise any such risk.
  2. Change in total body skin colour – This is an extremely rare occurrence. It has been reported that some patients noted their skin to become darker (like a suntan) for a period of weeks after treatment with intravenous iron. This was not permanent and resolved after several weeks.
  3. Allergy – historically intravenous iron preparations carried a risk of allergy (ranging from a mild reaction like itchy skin through to anaphylaxis that could be life threatening). With today’s modern iron preparation this is uncommon (1 in a 100 to 1 in a 1000 risk). Please inform the nurse caring for you immediately if you experience any of the following during your treatment (swelling of lips, tongue, face or throat, shortness of breath, itching, a feeling of all over body heat, heart racing heat or faint like symptoms)
  4. Delayed reaction – Although uncommon, some patients may experience muscle or joint pains and fever in the days after treatment. This usually lasts two to four days and can be managed with simple painkillers like paracetamol Iron infusions are commonly used after the first trimester in pregnancy. It is important that you also read the patient information leaflet for the product.

Your anaemia/ low blood count is expected to improve.

If you are taking oral iron, you should stop this the day before you come into our clinic for your Iron Infusion.

Within our treatment room at our Bolton Health Centre.

You may rarely experience muscle or joint pains; these can be managed with simple painkillers such as paracetamol.

Simple painkillers for any joint pain can be taken when you go home following your completed monitoring period at our clinic.

It is not anticipated that your iron infusion will affect your ability to undertake your usual activities.

Your nurse will let you know if you need to come back for a further infusion in about a weeks’ time and they may advise you at this time regarding any blood tests that are needed.

It is not anticipated that your iron infusion will affect your ability to undertake your usual activities.

If left unaddressed, iron deficiency can have significant long-term health consequences. Beyond the fatigue and discomfort it causes, untreated iron deficiency can severely impact your quality of life, affecting daily activities, work productivity, and general well-being. It’s crucial to identify and manage iron deficiency before it progresses to more severe forms, such as anaemia.

Although you consent for this treatment, you may at any time after that withdraw such consent. Please discuss this with your medical team.

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