Erythrocytosis2025-05-20T13:54:18+01:00

Erythrocytosis

Erythrocytosis is a condition in which your body produces too many red blood cells (RBCs). This increases the thickness (viscosity) of your blood, making it harder to flow smoothly through your blood vessels and increasing the risk of blood clots, heart attacks, or strokes.

It is sometimes referred to as polycythaemia, especially when caused by bone marrow disorders.

Erythrocytosis Overview

Understanding Causes, Symptoms, and Risk Factors

Causes

Erythrocytosis can be primary (due to a problem in the bone marrow) or secondary (due to another condition or factor).

Primary Erythrocytosis
Polycythaemia vera (PV) is a A rare blood cancer caused by a mutation in the JAK2 gene, leading to uncontrolled RBC production.Secondary Erythrocytosis

  • Chronic low oxygen (hypoxia) due to lung disease (e.g. COPD), sleep apnoea or living at high altitudes

  • Tumours producing erythropoietin (EPO) from kidney, liver, or adrenal gland tumours

  • Kidney disease

  • Anabolic steroid use

  • Congenital heart disease

  • Smoking

  • Dehydration (relative erythrocytosis)

Symptoms

  • Headaches
  • Dizziness or lightheadedness
  • Blurred vision
  • Red or flushed skin (especially face)
  • Itching (particularly after a hot shower – in PV)
  • Fatigue
  • High blood pressure
  • Numbness or tingling in hands and feet
  • Enlarged spleen (splenomegaly)

If left, untreated may increase the risk of blood clots, stroke or a heart attack.

Risk Factors

Genetic erythrocytosis can run in families associated with the JAK2 gene mutation.

More common in men than women.

Conditions such as chronic lung disease and kidney disorders.

Can Erythrocytosis be prevented?

Primary erythrocytosis cannot be prevented however secondary erythrocytosis can be prevented.

Secondary Erythrocytosis can prevented by managing the underlying condition and maintaining  adequate hydration.

How Chequers can help Diagnose and Treat

Venesection

Patient having an iron infusion by a clinician

An effective treatment for Erythrocytosis.


Preventive, Trusted, and Affordable Healthcare for All

Chequers Health is a well-known private healthcare provider in Bolton. It is registered with the CQC and trusted by many patients in the Northwest of England. Our dedicated team is committed to providing personalised care tailored to each patient’s unique needs and exceptional care.

Fast Appointments
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Had an amazing experience here today. Staff were super friendly, facilities are very good and very clean!

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Our Clinicians

At Chequers Health, our specialists blend expertise, compassion, and convenience to deliver the care you deserve. We prioritise quick access and personalised care, ensuring that your health needs are addressed promptly and effectively by trusted professionals.

Dr Ushma Meswani, BSc. (MBBS), MD, MRCP, FRCPath
Dr Ushma Meswani, BSc. (MBBS), MD, MRCP, FRCPath
Dr. Maged Gharib MBChi, MSc, MD, FRCP, FRCPath
Dr. Maged Gharib MBChi, MSc, MD, FRCP, FRCPath

Frequently Asked Questions

You will need to come into clinic for a short period of time before the infusion, for the duration of the infusion and you will then be asked to stay for further monitoring for about 30 minutes after the infusion.

Oral iron is used initially to treat iron deficiency anaemia. Sometimes this does not produce enough of an improvement, or it may be that your doctor needs to replenish your iron quickly. Intravenous iron is used when oral iron has been tried or if it is not suitable and it helps to reduce the use of blood transfusions.

Intravenous iron is an extremely safe and effective therapy. Some of the side effects that have been reported are:

  1. Staining – If your cannula was to displace from your vein during treatment the drug could be deposited in your skin rather than into your bloodstream. This could result in a brown stain to the skin. If you notice pain at the injection site during your treatment, please inform the nurse caring for you immediately. This will minimise any such risk.
  2. Change in total body skin colour – This is an extremely rare occurrence. It has been reported that some patients noted their skin to become darker (like a suntan) for a period of weeks after treatment with intravenous iron. This was not permanent and resolved after several weeks.
  3. Allergy – historically intravenous iron preparations carried a risk of allergy (ranging from a mild reaction like itchy skin through to anaphylaxis that could be life threatening). With today’s modern iron preparation this is uncommon (1 in a 100 to 1 in a 1000 risk). Please inform the nurse caring for you immediately if you experience any of the following during your treatment (swelling of lips, tongue, face or throat, shortness of breath, itching, a feeling of all over body heat, heart racing heat or faint like symptoms)
  4. Delayed reaction – Although uncommon, some patients may experience muscle or joint pains and fever in the days after treatment. This usually lasts two to four days and can be managed with simple painkillers like paracetamol Iron infusions are commonly used after the first trimester in pregnancy. It is important that you also read the patient information leaflet for the product.

Your anaemia/ low blood count is expected to improve.

If you are taking oral iron, you should stop this the day before you come into our clinic for your Iron Infusion.

Within our treatment room at our Bolton Health Centre.

You may rarely experience muscle or joint pains; these can be managed with simple painkillers such as paracetamol.

Simple painkillers for any joint pain can be taken when you go home following your completed monitoring period at our clinic.

It is not anticipated that your iron infusion will affect your ability to undertake your usual activities.

Your nurse will let you know if you need to come back for a further infusion in about a weeks’ time and they may advise you at this time regarding any blood tests that are needed.

It is not anticipated that your iron infusion will affect your ability to undertake your usual activities.

If left unaddressed, iron deficiency can have significant long-term health consequences. Beyond the fatigue and discomfort it causes, untreated iron deficiency can severely impact your quality of life, affecting daily activities, work productivity, and general well-being. It’s crucial to identify and manage iron deficiency before it progresses to more severe forms, such as anaemia.

Although you consent for this treatment, you may at any time after that withdraw such consent. Please discuss this with your medical team.

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